
Monica Servin (MPOG Obstetric Subcommittee Chair): They present more
challenges.
Uterotonic Agents – MPOG data presented:
Administration by agents (see slides 14-15)
Agents and transfusion (see slide 16)
Agents and EBL (see slide 17)
Agents and transfusion stratified by EBL (see slide 18)
Discussion:
• Monica Servin (MPOG Obstetric Subcommittee Chair): Does anyone not use oxytocin as a first
line agent? Or is it pretty much what everyone uses?
o Wandana Joshi (Dartmouth): Yes, that’s our first line agent
o Ashraf Habib (Duke): Agree – our first line agent is also oxytocin
o Sonal Zambare (Baylor University): Yes, first line agent is oxytocin.
• Ashraf Habib (Duke): Unless Canadian sites, but in U.S. oxytocin is likely the first line agent for
most sites
• Brandon Togioka (OHSU): Not surprised that most common agent is Oxytocin. Am surprised to
see Misorostol as second line agent since it’s not as effective as others.
• Kim Finch (Henry Ford Health) in chat: Does anyone use TXA?
o Lee-lynn Chen (UCSF): Yes
• Monica Servin (MPOG Obstetric Subcommittee Chair): Methergine is most common second
medication to add for bleeding.
• Brian Waldman (Columbia): We use Misoprostol as 3
rd
option, given PR by nursing team.
• Wandana Joshi (Dartmouth): We don’t use carboprost so often definitely a further down the
road agent.
• Ashraf Habib (Duke): Typically, Methergine or Carboprost as the second-line agents
• Sharon Abramovitz (Weill-Cornell): Agree with all that, just wondering is anybody or any of the
obstetricians giving misoprostol intra myometrial during the C-section putting the tablets into
the uterus?
o Ashraf Habib (Duke): They do not at our hospital.
o Wandana Joshi (Darthmouth): I haven’t seen that done in years.
o Monica Servin (MPOG OB Subcommittee Chair): Does it seem to work better?
o Sharon Abramovitz (Weill Cornell): No
• Wandana Joshi (Dartmouth): Methergine but not prior to oxytocin. Methergine reduces rates of
transfusion in a journal article I recently read. (Will post to forum when she finds article).
• Monica Servin (MPOG Obstetric Subcommittee Chair): How is transfusion, not MTP, requested?
OBs vs Anesthesiologists?
o Ashraf Habib (Duke): Typically, the anesthesia team
• Sharon Abramovitz (Weill-Cornell): Phenylephrine rates? What’s considered as usual when
higher rates are required? Sparks transfusion conversation. When patients come to OR for spinal
anesthesia, adjustments are made. With ongoing bleeding, when we have to go up on the
infusion, communication to OB team is needed.
o Monica Servin (MPOG Obstetric Subcommittee Chair): Communication with OB team
would be a good area for process improvement.